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|Season premiere:||September 20, 2016|
|Season finale:||December 20, 2016|
- “Oh. My. Gauze.”
- — Season Two's Tagline
Season Two of Scream Queens was announced by Fox on January 15, 2016, after the company ordered a 10-episode season. Production for the second season began on February 18, 2016, and the season started airing on September 20, 2016 in its continued time slot on Tuesdays at 9PM EST on Fox. Filming officially began on July 19, 2016 in Los Angeles and ended on December 6, 2016.
- Related article: Timeline
Season Two graduates from the college campus and into an all-new location, as a terrifyingly funny murder mystery will begin once again. This time, the show will be set in a hospital, where some of the most fascinating and bizarre medical cases are under observation.
- Ryan Murphy, Brad Falchuk, and Ian Brennan officially started production of Season Two on February 18, 2016.
- Filming for the second season of Scream Queens officially began in Los Angeles at the Paramount lot on July 19, 2016 and concluded on December 6, 2016.
- Emma Roberts as Chanel Oberlin (10/10)
- Kirstie Alley as Ingrid Hoffel (7/10) (Episodes 1-2; 5-7; 9-10)
- Taylor Lautner as Dr. Cassidy Cascade (10/10)
- Lea Michele as Hester Ulrich (10/10)
- Abigail Breslin as Chanel #5 (10/10)
- Keke Palmer as Zayday Williams (9/10) (Episodes 1-6; 8-10)
- Billie Lourd as Chanel #3 (10/10)
- James Earl as Chamberlain Jackson (7/10) (Episodes 1-6; 8)
- John Stamos as Dr. Brock Holt (10/10)
- Jamie Lee Curtis as Cathy Munsch (10/10)
Special Guest Stars
- Niecy Nash as Denise Hemphill (7/10) (Episodes 1-5; 7; 10)
- Colton Haynes as Tyler (2/10) (Episodes 2-3)
- Trilby Glover as Jane Hollis (7/10) (Episodes 1; 3; 5-6; 8-10)
- Andrea Erikson Stein as Marguerite Honeywell (4/10) (Episodes 5-6; 8-9)
- Riley McKenna Weinstein as Daria Janssen (4/10) (Episodes 5-6; 8; 10)
- Glen Powell as Chad Radwell (3/10) (Episodes 2-4)
- Jerry O'Connell as Dr. Mike (3/10) (Episodes 1-3)
- Laura Bell Bundy as Nurse Thomas (3/10) (Episodes 1-3)
- Jeremy Batiste as Bill Hollis (3/10) (Episodes 1; 3; 5)
- Oliver Hudson as Wes Gardner (2/10) (Episodes 8-9)
- Kevin Bigley as Randal (2/10) (Episodes 2-3)
- Cecily Strong as Catherine Hobart (1/10) (Episode 1)
- Jocelyn Ayanna as Detective (1/10) (Episode 2)
- Brian Baumgartner as Richard (1/10) (Episode 2)
- Jay Whittaker as Marshall Winthrop (1/10) (Episode 2)
- Alec Mapa as Lynn Johnstone (1/10) (Episode 3)
- Cheri Oteri as Sheila Baumgartner (1/10) (Episode 3)
- Ivar Brogger as Mitch Mitchum (1/10) (Episode 4)
- Mary Birdsong as Penelope Hotchkiss (1/10) (Episode 5)
- Pablo Castelblanco as Tristan St. Pierre (1/10) (Episode 5)
- August Emerson as Brandon Szathmary (1/10) (Episode 6)
- Kasey Mahaffy as Thomas Benderhall (1/10) (Episode 7)
- Marissa Jaret Winokur as Shelly (1/10) (Episode 7)
- Amy Okuda as Anna Plaisance (1/10) (Episode 7)
- Bill Oberst, Jr. as Clark (1/10) (Episode 8)
- Brooke Shields as Dr. Scarlett Lovin (1/10) (Episode 9)
- Clayton Farris as Lenk Van D'Vlonne (1/10) (Episode 9)
- Ajay Mehta as Arthur Annenburg (1/10) (Episode 9)
- Dahlya Glick as Chanel #10 (3/10) (Episodes 5-7)
- Moira O'Neill as Chanel #9 (2/10) (Episodes 5-6)
- Carrie Gibson as Adelaide Ruddy (1/10) (Episode 1)
- Shaan Sharma as Alf (1/10) (Episode 1)
- Christina Leone as Audience Member (1/10) (Episode 1)
- Molly Durand as Punky Brewster (1/10) (Episode 1)
- Jayme Andrews as Driver (1/10) (Episode 1)
- Jill Johnson as Passenger (1/10) (Episode 1)
- Phil Abrams as Dean of Students (1/10) (Episode 1)
- Michael Saltzman as Keith Hernandez (1/10) (Episode 2)
- La'Charles Trask as Daryl Strawberry (1/10) (Episode 2)
- David Paul Sommer as Orderly (1/10) (Episode 2)
- Lorenzo Bastien as Douchebag #1 (1/10) (Episode 2)
- Tarik Woodbine as Douchebag #2 (1/10) (Episode 2)
- Gio Zavala as Guy (1/10) (Episode 2)
- Retta Aughtry as Susan (1/10) (Episode 4)
- Julia Boyd as Frumpy Girl #1 (1/10) (Episode 4)
- Nandini Bapat as Frumpy Girl #2 (1/10) (Episode 4)
- Carla Jeffery as Frumpy Girl #3 (1/10) (Episode 4)
- Aurora Antonio as Frumpy Girl #4 (1/10) (Episode 4)
- Jessica Evans as Frumpy Girl #5 (1/10) (Episode 4)
- Hayley Huntley as Snow White (1/10) (Episode 4)
- Jared Wernick as Alexander Hamilton (1/10) (Episode 4)
- Olivia May as Katy Perry (1/10) (Episode 4)
- Cathy Marks as Chanel #11 (1/10) (Episode 5)
- Alexander Harris as Bailiff (1/10) (Episode 5)
- Helen Hong as Phlebotomist (1/10) (Episode 6)
- Roy Fegan as Slade Hornborn (1/10) (Episode 7)
- Frank Birney as Old Man (1/10) (Episode 8)
- Tory N. Thompson as Garrett Larson (1/10) (Episode 9)
- David Aaron as Proctor (1/10) (Episode 9)
- Alixandra Von Renner as Set P.A. (1/10) (Episode 9)
- Etienne Maurice as Other P.A. (1/10) (Episode 9)
- Dan Gilvary as Justice Anthony Kennedy (1/10) (Episode 10)
- Maryam Cne as Waitress (1/10) (Episode 10)
- Christopher Chen as Manager (1/10) (Episode 10)
- Harvey Shield as Butler (1/10) (Episode 10)
- Joseph Alfieri as Administrator (1/10) (Episode 10)
|Image||Title||Original Airdate||U.S. Viewers (in millions)|
|1. "Scream Again"||September 20, 2016||2.24|
Years after the murderous events at Kappa House, Dean Munsch purchases an abandoned hospital under the guise of fixing the healthcare system in America. After recruiting surgeons, Dr. Brock Holt and Dr. Cassidy Cascade, as well as medical student Zayday Williams, the Dean shocks everyone when she enlists the services of the disgraced Chanels to join the ranks at the teaching hospital. Meanwhile, secrets from the hospital’s past begin to reveal themselves and a new killer surfaces.
|2. "Warts and All"||September 27, 2016||1.70|
A new patient with a hideous ailment visits the hospital in hope of a cure, but finds a love interest instead. Meanwhile, Chad returns to win Chanel back and, in the process, discovers a dark secret of Brock’s. Then, after another run-in with the killer, Munsch enlists the help of new Quantico special agent Denise Hemphill.
|3. "Handidates"||October 11, 2016||1.59|
Determined to find out who the killer is, Dean Munsch, Denise and the Chanels question Hester, as well as the sole survivor of the Halloween massacre. Chad accuses Brock of being the killer and makes a shocking proposal to Chanel. Meanwhile, a new patient with an outrageous disorder leads Chanel #3 and Cassidy to grow closer, and another victim crashes a celebration.
|4. "Halloween Blues"||October 18, 2016||1.43|
After the latest attack by the Green Meanie leaves everyone shocked and saddened, Dean Munsch and Denise, along with Hester, devise a plan to catch the killer by throwing a Halloween party in the hospital. Meanwhile, Chanel celebrates a different kind of Chanel-O-Ween and attempts to make contact with the killer’s latest victim from beyond the grave. Once the party begins, an outbreak surprises the hospital, leading Brock and Cassidy to jump into action, and another victim falls.
|5. "Chanel Pour Homme-Icide"||November 15, 2016||1.44|
After the terrifying events of Halloween, Dean Munsch is forced to notify the authorities of the murders occurring at the C.U.R.E. Institute, which surprisingly leads to an influx of new patients. Fed up with doing dirty work, Chanel concocts a plan to put the new patients to use by recruiting them to join the Chanels. Meanwhile, Zayday and Chanel #5 pay a visit to someone with ties to the hospital's past, and a new patient's ailment causes the hospital staff to go a little mad.
|6. "Blood Drive"||November 22, 2016||1.18|
After an influx of patents at the C.U.R.E Institute, Dean Munsch and Chanel organize a blood drive to solve the hospital's severe shortage. Meanwhile, Nurse Hoffel sets a plan of revenge in motion, Hester finds a way to join the hospital's staff and a shocking revelation involving the Green Meanie occurs.
|7. "The Hand"||November 29, 2016||1.34|
In an effort to secure positive press for the hospital, Dean Munsch pitches a risky surgery to Dr. Holt, whose hand begins expressing more of a wild and dangerous personality than ever before. Meanwhile, Chanel #3 forces Cassidy to undergo a psych test to find the root of his condition with surprising results, and Nurse Hoffel sets a devious plan in motion.
|8. "Rapunzel, Rapunzel"||December 6, 2016||1.18|
A man from Dean Munsch's past checks in to the C.U.R.E. institute with plans to win her back, causing a jealous Brock to further question his relationship with Chanel. Meanwhile, Zayday and Chamberlain devise a plan to discover the origins of the Green Meanie killer with shocking results.
|9. "Lovin the D"||December 13, 2016||1.13|
The Chanels are overwhelmed when their TV idol, Dr. Scarlett Lovin, visits the C.U.R.E. Institute. Meanwhile, Hester calls a Green Meanie summit as the killer(s) put their final kill plan into effect.
|10. "Drain the Swamp"||December 20, 2016||1.38|
- Hester's story-line was intended to mirror that of Lea Michele's favorite horror movie Silence of the Lambs.
- The hospital setting drew inspiration from the classic horror franchise Halloween, which was partially set in a hospital and starred Jamie Lee Curtis in four installments.
- There was originally supposed to be three new male doctors, but only two ended up being cast, Dr. Brock Holt and Dr. Cassidy Cascade.
- There was supposed to be a two year time jump between the end of Season One and the beginning of Season Two, thus taking place in 2018; however, the premiere of the second season set the current events in 2016.
|Season One • Season Two|